Clinical findings of Talaromyces marneffei infection among patients with anti-interferon-γ immunodeficiency: a prospective cohort study

Abstract Background Talaromyces marneffei ( T. marneffei) infection has been associated with adult-onset immunodeficiency due to anti-IFN-γ autoantibodies. We aimed investigate the clinical features of non-HIV-infected patients in southern China. Methods Between January 2018 and September 2020, we enrolled who were HIV-negative (group TM, n = 42), including autoantibody-positive TMP, 22) autoantibody-negative TMN, 20) healthy controls HC, 40). Anti-IFN-γ autoantibodies detected by ELISA. Clinical characteristics laboratory parameters recorded. Results Compared infection, did not have underlying respiratory disease; more frequently exhibited dissemination systemic infections severe pleural effusion; had higher WBC counts, C-reactive protein levels, erythrocyte sedimentation rates, neutrophil CD8 + T cell counts; lower hemoglobin levels; likely other intracellular pathogen infections. Most these poor outcomes despite standardized antimicrobial therapy. Conclusion -infected autoantibody titers disease complex conditions.